Keto Pitfalls, Hearing Loss, Lab-Grown Heart


You could have not too long ago seen articles in regards to the long-term unfavourable results of a ketogenic food regimen, a brand new drugs that might reverse listening to loss, and the primary transplant of lab-grown coronary heart tissue. Here’s why you did not see them on Medscape Medical News.

Keto’s Expiration Date

Eating a ketogenic food regimen excessive in fats with minimal carbohydrates burns fats and restrains irritation at first, however in the long run, it causes weight acquire and impairs metabolic well being, researchers finding out mice report within the journal Nature Metabolism. The researchers discovered that when the mice first began on the ketogenic food regimen, their metabolically protecting gamma delta T cells proliferated, however over time on the food regimen, they misplaced these cells. Without these protecting immune cells, mice “have impaired glucose homeostasis,” the authors write.

Given the restricted long-term analysis on the ketogenic food regimen’s results in folks, it is tempting to take the outcomes of this research in mice and run with them. But as a result of our clinician readers are treating human sufferers, not mice, we did not cowl this analysis, which does not have clear cross-species relevance.

Hearing Loss Medicine

Combining the hormone aldosterone with an anti-inflammatory medicine can gradual listening to loss, in keeping with a information report that cited the work of Robert D. Frisina, PhD, director of biomedical engineering on the University of South Florida’s College of Engineering. “In a sense, we’re making the ear younger because we’re giving this critical hormone,” Frisina mentioned within the report. “It could be for everyone because we’re all going to lose our hearing as we get older.”

Frisina envisions this remedy working finest as a patch fairly than a tablet, however neither appears to have been examined in sufferers but. His patent utility cites in vitro and mouse experiments, and a scientific trial of aldosterone to deal with listening to loss doesn’t look like listed within the on-line repository ClinicalTrials.gov. Without proof of how nicely Frisina’s thought would possibly work within the clinic, we did not see something on this story that might be related for our readers.

Lab-Grown Heart Tissue Transplant

In an obvious world first, a staff of scientists at Osaka University in Japan transplanted cardiac muscle cell sheets grown from induced pluripotent stem cells right into a affected person with ischemic cardiomyopathy, the researchers introduced at a information convention. The transplant is a part of a scientific trial the investigators hope will enroll 10 sufferers in three years. “I hope that [the transplant] will become a medical technology that will save as many people as possible, as I’ve seen many lives that I couldn’t save,” cardiovascular surgeon Yoshiki Sawa mentioned.

Given the scarcity of donor hearts accessible for transplant for sufferers who want them, growing various remedies is an admirable purpose, and utilizing lab-grown stem cells sounds intriguingly excessive tech. But an experimental surgical procedure that has been carried out in a single particular person is just not typically one thing clinicians can supply their sufferers, particularly when the remedy and its final result haven’t been described and evaluated in a peer-reviewed medical journal. We did not suppose our readers wanted to find out about this process fairly but.

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