Scientists Are Calling For PNAS To Retract A Controversial Face Mask Study

More than 40 scientists, together with main epidemiologists learning COVID-19, are calling on a prime journal to retract a paper from a Nobel Prize–successful chemist that claimed that carrying face masks is the essential think about slowing the unfold of the coronavirus — diminishing the function that social distancing measures play in defending the general public.

The scientists, who despatched a signed letter to the journal PNAS on Thursday, say that the paper relies on false statements and flawed statistical evaluation and will encourage folks to place themselves in danger by congregating in teams, believing that carrying a masks is sufficient to defend them from an infection.

“One of the things we really worry about is that people will take this as rigorous science and base their actions on it,” Noah Haber, a postdoctoral researcher at Stanford University who helped arrange the letter calling for the paper’s retraction, instructed BuzzFeed News.

The paper was revealed on June 11 in PNAS, the flagship journal of the celebrated National Academy of Sciences, by researchers together with Mario Molina of the University of California, San Diego. Molina is an atmospheric chemist who shared the 1995 Nobel Prize in Chemistry for his analysis displaying how chemical compounds referred to as CFCs, as soon as broadly utilized in aerosol sprays and as refrigerants, have been destroying the ozone layer that protects us from the solar’s damaging ultraviolet rays.

Recently, mandates to put on face masks have grow to be a flashpoint within the hyper-politicized debate over restrictions to cease the unfold of COVID-19.

As scientists have discovered extra concerning the function folks with out seen signs play in spreading the illness, well being officers have really helpful widespread use of face coverings. And a scientific overview of the out there proof revealed on June 1 within the Lancet concluded that carrying masks “could result in a large reduction in risk of infection.”

Molina’s PNAS paper went a lot additional, nevertheless, claiming that airborne transmission by way of microscopic droplets is the “dominant” method during which the coronavirus spreads. Molina’s crew additionally estimated that guidelines requiring the carrying of masks prevented not less than 66,000 coronavirus infections in New York City between April 17 and May 9, and 78,000 infections in Italy between April 6 and May 9.

Neither of these conclusions is justified by the proof, the paper’s critics say. Still, the findings have been shared broadly on social media and coated uncritically by some information shops together with Forbes and the Los Angeles Times.

Soon after the paper appeared on-line, different scientists began posting eviscerating critiques of its assumptions and strategies on Twitter. “There were just so many errors and issues with the paper that it almost seemed hard to know where to start,” Kate Grabowski, an epidemiologist at Johns Hopkins University who signed the letter calling for the examine’s retraction, instructed Buzzfeed News.

On June 12, Grabowski posted that 4 scientists with the 2019 Novel Coronavirus Research Compendium, an knowledgeable group shaped at Johns Hopkins to supply assessments of recent analysis on the virus, had reviewed the paper and agreed that it needs to be retracted.

“The paper made extraordinary claims about routes of transmission, the effectiveness of mask-wearing, and by implication, the ineffectiveness of other non-pharmaceutical interventions. While we agree that mask-wearing plays an important role in slowing the spread of COVID-19, the claims in this study were based on easily falsifiable claims and methodological design flaws,” the letter says. “Given the scope and severity of the issues we present, and the paper’s outsized and immediate public impact, we ask that the Editors of PNAS retract this paper immediately.”

The largest drawback with the paper, based on Grabowski, is that its conclusions concerning the effectiveness of mask-wearing, in comparison with different measures to gradual the unfold of the virus, are based mostly on false statements.

Molina’s crew assumed that the one distinction between New York City and the remainder of the US by way of regulatory measures to restrict the unfold of COVID-19 was a mandate that folks ought to put on face coverings outdoors the house, launched in New York City on April 17. The paper additionally said: “With social distancing, quarantine, and isolation in place worldwide and in the United States since the beginning of April, airborne transmission represents the only viable route for spreading the disease.”

Neither of these assumptions is true, Grabowski and different signatories say, which suggests the conclusion that mask-wearing is the essential intervention simply doesn’t maintain up.

“There was a patchwork of varying behaviors and rules with varying degrees of adoption,” Daniel Larremore, a computational biologist on the University of Colorado at Boulder, who additionally signed the letter, instructed BuzzFeed News. He is learning knowledge on folks’s actions offered by Facebook and different expertise corporations, and has discovered that some folks continued to maneuver round even when stay-at-home orders have been in place.

What’s extra, there may be proof from a number of research that isolation and social distancing measures have slowed transmission of the coronavirus.

The letter requesting the paper’s retraction additionally slams the statistical strategies utilized by Molina’s crew. The researchers fitted straight strains to curves displaying the rising variety of instances, famous the timing of any mandate to put on face masks, after which checked out how the slope of the curve turned extra shallow after that. But this ignores the truth that case curves for infectious ailments are inclined to naturally degree out after a sure time period — which suggests it’s unimaginable to attribute the change to face masks alone.

Molina’s crew additionally ignored the lag of 1 to 2 weeks, brought on by the illness’s incubation interval and delays in analysis, wanted to see any noticeable impact on case numbers after a coverage change.

Contacted by BuzzFeed News earlier than the letter requesting retraction was despatched to PNAS, Molina rejected criticisms of his paper. “We just looked at the data that is published and it’s surprisingly linear until something happens,” Molina instructed BuzzFeed News.

Molina argued that epidemiologists have ignored the significance of microscopic droplets containing the virus. Specialists in air air pollution, he argued, are used to serious about the risks of aerosols of tiny particles. “This is obvious to people who deal with air quality,” he stated. “The only thing new here is that we apply this to the coronavirus.”

Other authors of the paper embrace Renyi Zhang, a former scholar of Molina’s who’s now a professor of atmospheric chemistry at Texas A&M University in College Station, and his daughter Annie Li Zhang, who was an undergraduate scholar in chemistry on the University of Texas at Austin.

Renyi Zhang declined to talk to BuzzFeed News. “This paper is a peer-reviewed scientific publication. Its content can be debated in a legitimate, scientific fashion. However, we prefer not to engage in scientific debates via social media platform,” he instructed BuzzFeed News by e mail, referring to criticisms of the paper on Twitter.

Annie Li Zhang didn’t reply to requests for touch upon her function within the analysis.

The struggle over the paper additionally exposes long-running considerations a couple of quirk of the journal PNAS that enables members of the academy, like Molina, to bypass the conventional mechanism of peer overview, by which journal editors choose impartial scientific consultants to vet a paper for publication.

Under the journal’s “contributed track,” academy members can submit as much as two papers a 12 months for which they choose the reviewers themselves. Some scientists have criticized the apply as an anachronism that enables the publication of substandard work and perpetuates the picture of the academy as an “old boys’ club.” The letter requesting the retraction of the paper additionally calls on PNAS to “reassess the Contributed Submission editorial process by which it was published.”

Academy members have to this point been unwilling to surrender this perk, however over time the foundations for the contributed monitor have been tightened, decreasing how regularly it may be used. Journal insurance policies additionally demand that “the subject matter must be within the member’s area of expertise.”

Yet not one of the authors of Molina’s paper, and neither of the reviewers, are consultants in infectious illness epidemiology.

Responding to queries from BuzzFeed News earlier than the letter requesting retraction, PNAS Editor-in-Chief May Berenbaum, an evolutionary biologist on the University of Illinois at Urbana-Champaign, stated by e mail that she was conscious of the criticisms of the paper.

“There are ongoing discussions about the paper among members of the journal leadership team, members of the Editorial Board, and other NAS members,” she stated, including that she was “awaiting additional information” on whether or not the publication of the paper had complied with the foundations for the contributed monitor.

Berenbaum didn’t instantly reply to a request for remark concerning the letter calling for the paper’s retraction.

This isn’t the primary controversy surrounding analysis on COVID-19, as scientists from many fields have rushed in to answer the disaster. In the early days of the pandemic, there was widespread concern that “preprints” of research, posted on-line with out peer overview, have been stoking misinformation and panic. In April, a high-profile Stanford antibody examine launched as a preprint was criticized for its flawed methodology and undisclosed battle of curiosity.

And earlier this month, high-profile papers revealed within the Lancet and the New England Journal of Medicine have been retracted after Surgisphere, a small firm that claimed to have offered well being information collected from tens of hundreds of sufferers, was unable to reveal the information behind the research.

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